منابع مشابه
Cisplatin-induced emesis in Suncus murinus.
Emetic responses to cisplatin and participation of vagal innervation in emesis were studied in suncus. Intraperitoneal and intravenous administration of cisplatin caused dose-dependent emesis. ED50 values, latencies and frequencies were not significantly different between the two administrations. Cis-diaqodiammineplatinum (DAP), an active metabolite of cisplatin, also induced emesis, but with s...
متن کاملEvaluating the various phases of cisplatin-induced emesis in rats
Use of cisplatin as a chemotherapeutic agent causes acute and delayed emesis. Kaolin, saccharin solution and normal feed consumption have been evaluated as an index of cisplatin-induced emesis in rats; however, the most preferable of these methods for evaluating the various phases of emesis remains unclear. In the current study, kaolin, saccharin solution and normal feed consumption following c...
متن کاملEffect of Nagarmotha (Cyperus rotundus Linn) on reserpine-induced emesis in pigeons.
Nagarmotha roots were obtained from a local dealer of Ayurvedic medicines, identified and a suspension containing 80 mgiml of the drug '\as prepared in ion free distilled water using gum acasia as suspending agent. Healtr.y pigeons weighing between 200-300 g were divided into four groups of 10 each. They were fed with grain (Jwar) in the morning and the experiments were performed at II a.m. Gro...
متن کاملOndansetron and Granisetron in the Prophylaxis of Nausea and Emesis Induced by Cisplatin in Dogs
Topal A. , M. Kaya, N. Gül: Ondansetron and Granisetron in the Prophylaxis of Nausea and Emesis Induced by Cisplatin in Dogs. Acta Vet. Brno 2005, 74: 111-116. In the present study, the effects of 5-HT3 receptor antagonist granisetron and ondansetron on the acute phase of cisplatin-induced nausea and emesis were analyzed in dogs. Fifteen healty dogs were used in this study. Cisplatin was admini...
متن کاملEfficacy & tolerability of ondansetron compared to metoclopramide in dose dependent cisplatin-induced delayed emesis.
BACKGROUND & OBJECTIVES Delayed emesis with cisplatin is a significant problem, which is often poorly controlled with conventional antiemetics. There is a relative paucity of data on the control of delayed emesis and rather inconsistent results have been reported. The present study aimed to compare the efficacy and tolerability of ondansetron versus metoclopramide in dose related grades of cisp...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48883-5